COVID-19 and Coronary Heart Disease

Coronary heart disease (CHD) is the leading cause of mortality worldwide. One main contributions and morbidity in CHD patients acute myocardial infarction (AMI), which result abrupt occlusion an epicardial coronary artery due to a sudden rupture atherosclerotic plaque, causing ischemia. In initial stage ischemia, lack oxygen nutrient supply results biochemical metabolic changes within myocardium. Depletion switches aerobic cellular metabolism anaerobic impairs oxidative phosphorylation pathway eventually cardiomyocyte death. Several studies suggest interlink between COVID-19 ischemic disease. An increased ACE2 receptor expression myocardium may partly contribute injuries that are observed affected by SARS-CoV-2. Furthermore, pre-existing cardiovascular disease, conjunction with aggravated inflammatory response causes up-regulation pro-inflammatory cytokines. Moreover, atherosclerosis be more prone attacks when COVID-19, hypercoagulation blood as well elevated markers.